© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Apolitical, amoral, an aesthete whose writings point toward some form of liberation: this is the figure who emerges from most recent scholarship on Friedrich ...

A collection of dramatic accounts about doctors who have faced the moral dilemma of choosing between obeying rules and doing what is best for a patient offers insight into the essential principles of medical ethics and their impact on ...

We often lament our limited nature as human beings. Supernatural is certainly no stranger to this theme and often contrasts the many weaknesses of man to the awesome power of angels, demons, and otherworldly creatures. It should be enough to show that angels can reasonably be atheists by showing two things. First, the best arguments in favor of the existence of God are no better if Anna and Cas think about them, and second, that these angels are also in no (...) better position than we are to deny what is perhaps the strongest argument against the existence of God. The cosmological argument for the existence of God begins with a couple of observations about the universe. The first is pretty obvious‐“things exist.” The second is that everything that exists was caused to exist as it is. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Cognitive control is easy to identify in its effects, but difficult to grasp conceptually. This creates somewhat of a puzzle: Is cognitive control a bona fide process or an epiphenomenon that merely exists in the mind of the observer? The topiCS special edition on cognitive control presents a broad set of perspectives on this issue and helps to clarify central conceptual and empirical challenges confronting the field. Our commentary provides a summary of and critical response to each of the papers.

First drafted in 2006 and currently in version 2.1, the London Charter calls for the adoption of international standards for intellectual integrity, transparency, sustainability, and access in 3D modeling for cultural heritage. While the London Charter has been in the process of revision and distribution to the heritage community, game engines have become less expensive and more approachable. Several engines offer the ability to publish easily across operating systems, mobile devices, and the web, causing a rapid expansion in their use (...) for archeological visualization. However, the very power of game engines to create and publish immersive content poses fundamental challenges to the emphasis on data-driven visualization and transparency expressed in the London Charter. These challenges should not be suppressed, since they can prove heuristically fruitful if they are explicitly recognized and explored. This potential is illustrated by a descriptive analysis of the recreation of the House of the Prince of Naples in Pompeii by an undergraduate humanities class, which concludes that the immersive effects of engine-based visualizations are as much to be found in their creation as in their “playing.” This suggests the value of democratizing the creation of game engine content for heritage visualization beyond research visualization laboratories, as a part of undergraduate curricula in the humanities. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2014 Heft: 202 Seiten: 533-553.

Wallace-Hadrill's reading of spatial hierarchy does not address the representation of gender in mythological paintings. However, a rough survey indicates that the majority are erotic and/or violent. Erotic depictions common on household items suggest that the Romans were sensitive to this content; the likely use of pattern books in selecting programs for domestic decoration suggests a synoptic awareness of it. This points to the applicability of contemporary theories of representation and power, and Mulvey's model of visual pleasure in narrative film (...) is adapted for this paper. According to Mulvey, film offers two pleasures: scopophilia, which presents the woman as aesthetic-erotic fragments, suggesting but concealing her difference ; sadistic voyeurism, which assumes difference and then investigates, punishes, or forgives it. Both are illustrated in paintings of Ariadne abandoned and rediscovered, and in other paintings which portray either the gaze or erotic violence . While these paintings seem to confirm in relation to gender what the rest of the house says about class and status, some paintings confuse the issue. The male body is often fetishized , and attacked ; gender and role are sometimes deliberately ambiguous . Such transgressions of the boundaries of the male body are not a part of Mulvey's theory, and they suggest the use of gender to complicate as well as confirm the class/status message of the house; two different negotiations of this use are found in the House of the Vettii and the House of the Ara Maxima. One can compare reversals and reassertions of gender, class and status in other evidence, in literature, pantomime and the games. (shrink)

The purpose of this paper is to outline an ethics development activity that uses scenarios in university classes to further the knowledge, engagement, and enhancement of the ethical actions of the students. By starting with a brief review of the objective and use of scenarios in ethics research, the paper progresses to explain the activity, debrief the activity, and finally to provide an analysis of the activity with examples. Included in this activity are ways to incorporate a discussion of Kant’s (...) Categorical Imperative Theories, NCA Credo of Ethical Communication, and the use of videos for Milgram’s Blind Obedience and Stanford’s Prison studies—thus making this activity useful across all disciplines. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

The rise of the sitar from a limited accompaniment instrument used in the regional courts of Northern India to an internationally recognized cultural icon underscores its importance both as an instrument and a cultural symbol—the sitar mirrors India’s social complexity. This story encapsulates the social, political and economic trauma resulting from the dismantling of Mughal empire to the partition of Pakistan, reflecting contesting social narratives and Hindu/Muslim cultural heritages through the distinctive musical styles modern India. A musical instrument and material (...) object of contested origins, the sitar extends from wood, gourd, wire, and ivory into complex social and cultural networks. I argue that the sitar, as object, cannot be reduced to either an empirical or phenomenological entity; it is a space of potentiality, the actualization of a virtual object. I examine the sitar as both byproduct and narrative, demonstrating how it defies attempts to limit its constantly rupturing borders with imposed cognitive frames, and how materiality and philosophical systems can inform ethnographic practice. (shrink)

The community of faith finds blessing for itself when it gives due weight to the Old Testament insight that nearness to God is found by those who, like Job and Jacob, assertively engage the Covenant Partner.

The community of faith finds blessing for itself when it gives due weight to the Old Testament insight that nearness to God is found by those who, like Job and Jacob, assertively engage the Covenant Partner.

In the parable of the Pharisee and the Tax Collector, Jesus trades in the language of hyperbole: The Pharisee and the tax collector are both caricatures of a particular way of responding to God. In itself each of these ways is not without its legitimacy. Nevertheless, the reason the Pharisee incurs God's disapproval in Jesus9 parable has to do with his misuse of religious tradition: Keeping the tradition becomes the means by which he exalts himself over others. Still, the tax (...) collector, too, can stand as a warning: Lamenting one's sins, if it does not lead to commensurate action, merely becomes an exercise in cheap grace. (shrink)

This is a welcome reprint of a book that continues to grow in importance.

In recent literature, panpsychism has been defended by appeal to two main arguments: first, an argument from philosophy of mind, according to which panpsychism is the only view which successfully integrates consciousness into the physical world (Strawson 2006; Chalmers 2013); second, an argument from categorical properties, according to which panpsychism offers the only positive account of the categorical or intrinsic nature of physical reality (Seager 2006; Adams 2007; Alter and Nagasawa 2012). Historically, however, panpsychism has also been defended by appeal (...) to a third argument based on considerations about the nature and observability of causation. This argument has not been much discussed in recent times. Here is a concise version from William James: "… the concrete perceptual flux, taken just as it comes, offers in our own activity-situations perfectly comprehensible instances of causal agency … If we took these experiences as the type of what actual causation is, we should have to ascribe to cases of causation outside of our life, to physical cases also, an inwardly experiential nature. In other words, we should have to espouse a so-called “pan-psychic” philosophy" (James 1911: 218). James here suggests that we have direct experience of causation in our own agency. He thereby directly contradicts David Hume, who famously denied that we have any experience of causation. James goes on to claim that if this experience is representative of causation in general, it follows that all causation is mental, and that panpsychism is true. This kind of argument for panpsychism can be called the argument from (experience of) causation. This chapter offers, first, a history of this argument and arguments closely related to it, and second, an analysis of the argument – is it valid, are its premises in any way defensible, and how does it relate to the other, more popular arguments for panpsychism from philosophy of mind and categorical properties? (shrink)

The author presents and defends three theses: (1) "the first is that it is not profitable for us at present to do moral philosophy; that should be laid aside at any rate until we have an adequate philosophy of psychology." (2) "the second is that the concepts of obligation, And duty... And of what is morally right and wrong, And of the moral sense of 'ought', Ought to be jettisoned if this is psychologically possible...." (3) "the third thesis is that (...) the differences between the well-Known english writers on moral philosophy from sidgwick to the present day are of little importance." (staff). (shrink)

In this essay, the author describes how he faced institutionalized homophobia during his psychiatric training, and how he later wrote a play inspired by the life of a gay psychiatrist. Despite Freud’s supportive stance, homosexuality aroused the antipathy of American organized psychiatry and psychoanalysis and came to be listed as an illness in the Diagnostic and Statistical Manual. Dr. John E. Fryer outed himself as “Dr. H Anonymous” at a 1972 meeting of the American Psychiatric Association, and the next year (...) homosexuality was removed from the DSM. The 2014 play Doctor Anonymous offers a fictionalized account of this watershed moment in the history of the gay rights movement. The author discusses his own psychotherapeutic work with gay male patients, including those who had previously been treated with conversion therapy, and explores how the play mirrors his own life experience and the experience of his patients. (shrink)

This is the first comprehensive study of Nietzsche's earliest (and extraordinary) book, The Birth of Tragedy (1872). When he wrote it, Nietzsche was a Greek scholar, a friend and champion of Wagner, and a philosopher in the making. His book has been very influential and widely read, but has always posed great difficulties for readers because of the particular way Nietzsche brings his ancient and modern interests together. The proper appreciation of such a work requires access to ideas that cross (...) the boundaries of conventional specialisms. This is now provided by M. S. Silk and J. P. Stern in their joint study of Nietzsche's book. They examine in detail its content, style and form; its strange genesis and hybrid status; its biographical background and the controversy engendered by its publication; its value as an account of ancient Greek culture and as a theory of tragedy and music; its relation to other theories of tragedy; and its place in the history of German ideas and in Nietzsche's own philosophical career. (shrink)

The goal of this study is to reconsider Nietzsche's early metaphysics. Nietzsche has been understood both as the last metaphysician and as the first western thinker to overcome metaphysics. Most of Nietzsche's readers who have been concerned with this issue, however, have concentrated entirely on his conception of the will-to-power which appears in his later work and have completely ignored his early artists-metaphysics which is only to be found in his first book, The Birth of Tragedy. If the metaphysical foundations (...) of this work are mentioned at all, readers assume that, because of the prominence awarded to the Apollinian and the Dionysian, the two art-drives are the first principles of the Artisten-Metaphysik. Based on this assumption, these same readers conclude that Nietzsche left his early metaphysics behind as he developed his conception of the will-to-power; the Artisten-Metaphysik has no relation to the will-to-power. ;In contrast to this treatment of the Artisten-Metaphysik, I argue that the first principle of Nietzsche's early metaphysics is the primordial-one , the world artist. On the basis of this hypothesis, I demonstrate that if the Ur-Eine is indeed the first principle of the Artisten-Metaphysik, the two art-drives are derivative of this principle. The Apollinian and the Dionysian burst forth from nature without the intervention of the human artist; each of the two art-drives represents a different creative tendency of the primordial artist. ;The significance of my re-evaluation of the Artisten-Metaphysik is far-reaching. Although previous interpretations of The Birth of Tragedy have prevented readers from seeing any connection between the early metaphysics and the will-to-power, my reconstruction of the Artisten-Metaphysik invites the reader to compare Nietzsche's early metaphysics with his later philosophical thought. And while I do not deny the differences between the Artisten-Metaphysik and the will-to-power, my interpretation enables the reader to appreciate the similarities between Nietzsche's early and his later philosophical work. Nietzsche is no longer understood as either the last metaphysician or the first western thinker to overcome metaphysics; rather, I emphasize the importance of Nietzsche's role as a transitional thinker in the western philosophical tradition. Indeed, Nietzsche emerges as one who adopts the will-to-power in an attempt to overcome metaphysics. And while he thinks of himself as an "untimely one" and one of the first thinkers to have overcome metaphysics, from the vantage point of this investigation elements of metaphysical thought may be identified in his philosophy. (shrink)

Background. The COVID-19 pandemic necessitated drastic changes to undergraduate medical training at the University of Botswana (UB). To save the academic year when campus was locked down, the Department of Medical Education conducted a needs assessment to determine the readiness for emergency remote teaching (ERT) of the Faculty of Medicine, UB. Objectives. To report on the findings of needs assessment surveys to assess learner and teaching staff preparedness for fair and just ERT, as defined by philosopher John Rawls. Methods. Needs (...) assessment surveys were conducted using Office 365 Forms distributed via WhatsApp, targeting medical students and teaching staff during the 5 undergraduate years. Data were analysed quantitatively and qualitatively. Results. Ninety-two percent (266/289) of students and 73.5% (62/84) of teaching staff responded. Surveys revealed a high penetration of smartphones among students, but poor internet accessibility and affordability in homes. Some teaching staff also reported internet and device insufficiencies. Only WhatsApp was accessible to students and teaching staff. Conclusions. For equitable access to ERT in the future, the surveys revealed infrastructural improvement needs, including wider, stronger, affordable WiFi coverage within Botswana and enhanced digital infrastructures in educational institutions, with increased support for students. (shrink)

Greek text, english translation and commentary on the surviving fragments of Empedocles (fragments as known in 1981, does not include more recent finds).